Alpha Arbutin
INCI: Alpha-Arbutin · Bearberry-derived glycoside
Mechanism of Action
Alpha Arbutin is a glycosylated hydroquinone derivative that competitively inhibits tyrosinase — the rate-limiting enzyme in melanin synthesis — without releasing free hydroquinone into the skin.¹² The alpha configuration is structurally more stable and a stronger tyrosinase inhibitor than the more commonly used beta form.²
Clinical Evidence
| Property | Detail |
|---|---|
| Depigmentation | Competitive tyrosinase inhibition, blocking new melanin production at the source.¹ |
| Safety vs. Hydroquinone | No free hydroquinone release — suited to ongoing daily use rather than short courses.¹ |
Formulation Rationale
Alpha Arbutin and Niacinamide interrupt pigmentation through different stages of the same pathway — production versus transfer — which is the basis for using both together rather than relying on a single mechanism.
Usage Protocol
Included at an effective concentration in the Face Serum, applied 2–3 drops twice daily.
Safety Profile
Generally well tolerated. Daily sunscreen is strongly recommended alongside any brightening active, since unprotected UV exposure can generate new pigmentation that offsets progress.
Where You'll Find It
Niacinamide 10% Face Serum (₹649)
Frequently Asked
Is this the same as hydroquinone?
Structurally related, but it does not release free hydroquinone in skin — a materially gentler safety profile.¹